Source code for vibeqc.solvation.cpcm

"""CPCM (Conductor-like Polarisable Continuum Model) -- core math (S1b).

The conductor-screening CPCM equations on a discrete cavity
tessellation are

    A q = - f(e) . V        with    f(e) = (e - 1) / e

where ``A`` is the (n_pts, n_pts) cavity self-interaction matrix,
``V`` is the gas-phase molecular electrostatic potential evaluated at
the cavity surface points, and ``q`` is the apparent surface charge.
The total solvation energy is

    E_solv = (1/2) S_i q_i V_i.

This module assembles ``A`` and solves for ``q``; the SCF wiring
lives in :mod:`vibeqc.solvation.driver`.

References
----------
* Klamt-Schüürmann 1993 -- original COSMO.
* Cossi-Rega-Scalmani-Barone 2003 -- CPCM matrix layout used here.
* Scalmani-Frisch 2010 -- diagonal element from continuous-surface-
  charge (CSC) formulation.
"""

from __future__ import annotations

from dataclasses import dataclass

import numpy as np

# Scalmani-Frisch (2010) diagonal constant.
#
#     A_ii = (CPCM_DIAG_ALPHA x √(4pi)) / √(w_i)
#          = (1.0694 x √(4pi))   / √(w_i)
#
# where ``w_i`` is the actual surface area element at the cavity point
# (bohr^2, so the dimensional units work out: 1 / √(bohr^2) = bohr⁻¹).
# The numerical factor 1.0694 is the self-energy of a uniformly charged
# disk relative to the equivalent Gaussian -- see Scalmani-Frisch 2010
# eq. (11) and Cossi-Scalmani-Mennucci-Tomasi 2003 eq. (18). The
# baked-in √(4pi) makes the diagonal dominant over typical nearest-
# neighbour 1/r off-diagonals on Lebedev-discretised spheres, which
# the bare 1.0694/√w_i form fails for moderately dense tessellations
# (110+ points per sphere).
#
# Matches PySCF (pyscf/solvent/pcm.py::PCM.get_F0) and Q-Chem (CPCM
# default; see Stratmann-Scuseria-Frisch JCP 109 8218).
import math as _math

CPCM_DIAG_ALPHA_BARE = 1.0694
CPCM_DIAG_ALPHA = CPCM_DIAG_ALPHA_BARE * _math.sqrt(4.0 * _math.pi)


def _native_cpcm():
    try:
        from vibeqc import _vibeqc_core as _core
    except ImportError:
        return None
    required = (
        "cpcm_build_A_matrix",
        "cpcm_build_capped_A_matrix",
        "cpcm_dielectric_factor",
        "cpcm_solve_apparent_charges",
    )
    if not all(hasattr(_core, name) for name in required):
        return None
    return _core


[docs] @dataclass(frozen=True) class CPCMResult: """Outcome of one apparent-surface-charge solve. Attributes ---------- q : ndarray, shape (n_pts,) Apparent surface charges, atomic units. V : ndarray, shape (n_pts,) Total molecular electrostatic potential (electron + nuclear) at the cavity points, atomic units. e_solv : float, Hartree Solvation energy E_solv = 1/2 S_i q_i V_i. epsilon : float Solvent dielectric constant used. """ q: np.ndarray V: np.ndarray e_solv: float epsilon: float @property def total_charge(self) -> float: return float(self.q.sum())
def build_A_matrix(cavity_points: np.ndarray, cavity_weights: np.ndarray) -> np.ndarray: """Assemble the CPCM cavity self-interaction matrix A. The diagonal uses Scalmani-Frisch's disk self-energy A_ii = a/√w_i (eq. 11 of their 2010 paper). The off-diagonal is the Coulomb kernel A_ij = 1/|s_i - s_j|. All inputs in atomic units (bohr for distances, bohr^2 for weights). The returned matrix is symmetric, positive-definite -- suitable for ``numpy.linalg.solve`` or a Cholesky. Memory is O(n_pts^2) doubles. For 240 cavity points that's ~440 KB; for 5000 cavity points that's ~190 MB -- typical of "tight Gaussian-default cavity on a 50-heavy-atom molecule". Use ``solve_apparent_charges`` to factor + solve in one shot. """ pts = np.asarray(cavity_points, dtype=np.float64) w = np.asarray(cavity_weights, dtype=np.float64) if pts.ndim != 2 or pts.shape[1] != 3: raise ValueError( f"cavity_points must be (n_pts, 3); got {pts.shape}" ) if w.shape != (pts.shape[0],): raise ValueError( f"cavity_weights must be (n_pts,); got {w.shape}" ) native = _native_cpcm() if native is not None: return np.asarray(native.cpcm_build_A_matrix(pts, w), dtype=np.float64) # Pairwise Euclidean distances (bohr) -- full NxN construction is # the same cost as the matvec and avoids a second loop later. diff = pts[:, None, :] - pts[None, :, :] dist = np.sqrt(np.einsum("ijk,ijk->ij", diff, diff)) # Off-diagonal: 1/r_ij. Diagonal will overwrite shortly. with np.errstate(divide="ignore"): A = 1.0 / dist # Scalmani-Frisch disk self-energy on the diagonal: A_ii = a/√w_i. # This stays finite for the smallest-weight (most heavily-switched) # points so A is positive-definite end-to-end. np.fill_diagonal(A, CPCM_DIAG_ALPHA / np.sqrt(w)) return A def dielectric_factor(epsilon: float, *, variant: str = "cpcm") -> float: """Conductor screening factor f(e). ``variant = "cpcm"`` (default) uses the Cossi-Scalmani-Barone factor ``f = (e - 1)/e`` -- converges smoothly to the conductor limit at high e. ``variant = "cosmo"`` uses the Klamt-Schüürmann factor ``f = (e - 1)/(e + x)`` with ``x = 0.5`` (the COSMO X parameter; Klamt 1993). The two differ by O(1/e) and agree to better than 1% above e ≈ 30 -- for water and most polar solvents the choice moves E_solv by ≲ 0.1 kcal/mol. """ native = _native_cpcm() if native is not None: try: return float( native.cpcm_dielectric_factor(float(epsilon), variant.lower()) ) except RuntimeError as exc: raise ValueError(str(exc)) from exc if epsilon <= 1.0: raise ValueError( f"dielectric_factor: epsilon must be > 1; got {epsilon} " f"(use variant='gas' or set solvent=None to skip CPCM)." ) v = variant.lower() if v == "cpcm": return (epsilon - 1.0) / epsilon if v == "cosmo": x = 0.5 return (epsilon - 1.0) / (epsilon + x) raise ValueError( f"dielectric_factor: unknown variant {variant!r} " f"(use 'cpcm' or 'cosmo')." ) def solve_apparent_charges( A: np.ndarray, V_at_cavity: np.ndarray, *, epsilon: float, variant: str = "cpcm", ) -> CPCMResult: """Solve A q = -f(e) V for the apparent surface charges. Returns a :class:`CPCMResult` carrying ``q``, ``V``, the solvation energy ``1/2 q.V``, and the dielectric used. The matrix ``A`` is factorised by ``numpy.linalg.solve`` -- for repeated solves with the same cavity, prefer caching a Cholesky outside (the cavity is fixed for the duration of one SCF macro-iteration set). """ V = np.asarray(V_at_cavity, dtype=np.float64).reshape(-1) if V.shape[0] != A.shape[0]: raise ValueError( f"solve_apparent_charges: V length {V.shape[0]} does " f"not match A shape {A.shape}" ) native = _native_cpcm() if native is not None: try: res = native.cpcm_solve_apparent_charges( np.asarray(A, dtype=np.float64), V, float(epsilon), variant.lower(), ) except RuntimeError as exc: raise ValueError(str(exc)) from exc return CPCMResult( q=np.asarray(res.q, dtype=np.float64), V=np.asarray(res.V, dtype=np.float64), e_solv=float(res.e_solv), epsilon=float(res.epsilon), ) f = dielectric_factor(epsilon, variant=variant) rhs = -f * V q = np.linalg.solve(A, rhs) e_solv = 0.5 * float(np.dot(q, V)) return CPCMResult(q=q, V=V, e_solv=e_solv, epsilon=float(epsilon))